GLAST/EAAT1-induced Glutamine release via SNAT3 in Bergmann glial cells: evidence of a functional and physical coupling
نویسندگان
چکیده
منابع مشابه
ATP-induced cytoplasmic calcium mobilization in Bergmann glial cells.
ATP receptor mediated Ca2+ signaling was recorded from Bergmann glial cells in cerebellar slices obtained from mice of different ages (postnatal days 6 to 45). To measure the cytoplasmic concentration of Ca2+ ([Ca2+]in), either individual cells were loaded with the Ca(2+)-sensitive probes using the whole cell patch clamp technique or slices were incubated with the dye and the microfluorimetric ...
متن کاملNeuron – Glia Signaling via a 1 Adrenoceptor - Mediated Ca 2 1 Release in Bergmann Glial Cells In
Adrenoceptors were among the first neurotransmitter receptors identified in glial cells, but it is not known whether these receptors meditate glial responses during neuronal activity. We show that repetitive nerve activity evoked a rise of intracellular calcium in Bergmann glia and neighboring Purkinje neurons of cerebellar slices of mice. The glial but not the neuronal calcium transient persis...
متن کاملThe role of Bergmann glial cells in cerebellar development
Correspondence A response to Gershon et al. : Hexokinase-2-mediated aerobic glycolysis is integral to cerebellar neurogenesis and pathogenesis of meduloblastoma. Cancer and Metabolism 2013, 1(2):17 Gershon et al. [1] have investigated the role that Hexokinase-2 (Hk2) plays in the control of aerobic glycolysis during cerebellar neurogenesis and pathogenesis of medulloblastoma. They conclude from...
متن کاملBergmann glial GlyT1 mediates glycine uptake and release in mouse cerebellar slices.
Glycine is an inhibitory neurotransmitter and is critical for NMDA receptor activation. These roles are dependent on extracellular glycine levels, which are regulated by Na(+)/Cl(-)-dependent glycine transporters (GlyTs) in neurones and glia. The glial GlyT subtype GlyT1 is well located to activate NMDA receptors. However, glial GlyTs have not been studied in an intact system thus far. Whole-ce...
متن کاملMotor Behavior Activates Bergmann Glial Networks
Although it is firmly established that neuronal activity is a prime determinant of animal behavior, relationships between astrocytic excitation and animal behavior have remained opaque. Cerebellar Bergmann glia are radial astrocytes that are implicated in motor behavior and exhibit Ca(2+) excitation. However, Ca(2+) excitation in these cells has not previously been studied in behaving animals. ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Neurochemistry
سال: 2013
ISSN: 0022-3042
DOI: 10.1111/jnc.12211